DetailsCDKN1A

Identification
Gene Name CDKN1A
Accession Number HAMDB930
Molecular Type kinase
Description Cyclin-dependent kinase inhibitor 1
Synonyms CDKN1A
Structure
Role in Autophagy
2 related item(s)

1. CDKN1A
Gene Name CDKN1A
Relationship with Autophagy decreased activity of CDKN1A increases autophagy of fibroblast cell lines
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Mouse
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 1
References
  1. Fujiwara K, Daido S, Yamamoto A, Kobayashi R, Yokoyama T, Aoki H, Iwado E, Shinojima N, Kondo Y, Kondo S, Pivotal Role Of The Cyclin-dependent Kinase Inhibitor P21waf1/cip1 In Apoptosis And Autophagy., J Biol Chem.2008 Jan 4;283(1):388-97. [PMID:17959603  ]

2. CDKN1A
Gene Name CDKN1A
Relationship with Autophagy decreased activity of CDKN1A increases autophagy of fibroblast cell lines
Mutation Evidence [homozygous, knockout]
Biomarker Application not applicable
Species Evidence Mouse
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 1
References
  1. Fujiwara K, Daido S, Yamamoto A, Kobayashi R, Yokoyama T, Aoki H, Iwado E, Shinojima N, Kondo Y, Kondo S, Pivotal Role Of The Cyclin-dependent Kinase Inhibitor P21waf1/cip1 In Apoptosis And Autophagy., J Biol Chem.2008 Jan 4;283(1):388-97. [PMID:17959603  ]
Biological Behaviors
Canonical Pathway
  1. AMPK Signaling
  2. Antiproliferative Role of Somatostatin Receptor 2
  3. Aryl Hydrocarbon Receptor Signaling
  4. ATM Signaling
  5. Bladder Cancer Signaling
  6. Breast Cancer Regulation by Stathmin1
  7. Cell Cycle: G1/S Checkpoint Regulation
  8. Cell Cycle: G2/M DNA Damage Checkpoint Regulation
  9. Chronic Myeloid Leukemia Signaling
  10. Cyclins and Cell Cycle Regulation
  11. Estrogen-mediated S-phase Entry
  12. GADD45 Signaling
  13. Glioblastoma Multiforme Signaling
  14. Glioma Signaling
  15. Glucocorticoid Receptor Signaling
  16. HER-2 Signaling in Breast Cancer
  17. Hereditary Breast Cancer Signaling
  18. HGF Signaling
  19. JAK/Stat Signaling
  20. Melanoma Signaling
  21. Molecular Mechanisms of Cancer
  22. p53 Signaling
  23. Pancreatic Adenocarcinoma Signaling
  24. PI3K/AKT Signaling
  25. Prostate Cancer Signaling
  26. PTEN Signaling
  27. Role of BRCA1 in DNA Damage Response
  28. Role of CHK Proteins in Cell Cycle Checkpoint Control
  29. STAT3 Pathway
  30. Telomerase Signaling
  31. VDR/RXR Activation
Targeted By miRNA
  1. let-7a-5p (and other miRNAs w/seed GAGGUAG)
  2. miR-103b (miRNAs w/seed CAUAGCC)
  3. miR-1197 (and other miRNAs w/seed AGGACAC)
  4. miR-1205 (miRNAs w/seed CUGCAGG)
  5. miR-1207-5p (and other miRNAs w/seed GGCAGGG)
  6. miR-1227-3p (miRNAs w/seed GUGCCAC)
  7. miR-1231-3p (and other miRNAs w/seed GCCCUGU)
  8. miR-1233-5p (and other miRNAs w/seed GUGGGAG)
  9. miR-1237-5p (and other miRNAs w/seed GGGGGCG)
  10. miR-1249-5p (and other miRNAs w/seed GGAGGGA)
  11. miR-1255b-5p (and other miRNAs w/seed GGAUGAG)
  12. miR-1273h-5p (and other miRNAs w/seed UGGGAGG)
  13. miR-1288-3p (miRNAs w/seed GGACUGC)
  14. miR-1304-5p (miRNAs w/seed UUGAGGC)
  15. miR-130a-3p (and other miRNAs w/seed AGUGCAA)
  16. miR-1343-5p (and other miRNAs w/seed GGGGAGC)
  17. miR-148a-3p (and other miRNAs w/seed CAGUGCA)
  18. miR-149-3p (and other miRNAs w/seed GGGAGGG)
  19. miR-1537-5p (miRNAs w/seed GCUGUAA)
  20. miR-15b-3p (miRNAs w/seed GAAUCAU)
  21. miR-17-5p (and other miRNAs w/seed AAAGUGC)
  22. miR-18a-5p (and other miRNAs w/seed AAGGUGC)
  23. miR-1908-5p (and other miRNAs w/seed GGCGGGG)
  24. miR-1909-3p (and other miRNAs w/seed GCAGGGG)
  25. miR-1914-3p (and other miRNAs w/seed GAGGGGU)
  26. miR-1953 (and other miRNAs w/seed GGGAAAG)
  27. miR-208a-3p (and other miRNAs w/seed UAAGACG)
  28. miR-21-5p (and other miRNAs w/seed AGCUUAU)
  29. miR-22-3p (miRNAs w/seed AGCUGCC)
  30. miR-224-5p (miRNAs w/seed AAGUCAC)
  31. miR-2277-3p (miRNAs w/seed GACAGCG)
  32. miR-290b-3p (and other miRNAs w/seed AGUGCCC)
  33. miR-291a-3p (and other miRNAs w/seed AAGUGCU)
  34. miR-292-3p (and other miRNAs w/seed AGUGCCG)
  35. miR-298 (miRNAs w/seed GCAGAAG)
  36. miR-298-5p (and other miRNAs w/seed GCAGAGG)
  37. miR-299a-5p (and other miRNAs w/seed GGUUUAC)
  38. miR-3083-5p (and other miRNAs w/seed GGCUGGG)
  39. miR-3104-5p (and other miRNAs w/seed AGGGGGC)
  40. miR-3108-3p (and other miRNAs w/seed GUCUAGG)
  41. miR-3126-5p (and other miRNAs w/seed GAGGGAC)
  42. miR-3127-3p (and other miRNAs w/seed CCCCUUC)
  43. miR-3145-5p (miRNAs w/seed ACUCCAA)
  44. miR-3150a-3p (and other miRNAs w/seed UGGGGAG)
  45. miR-3150b-3p (and other miRNAs w/seed GAGGAGA)
  46. miR-3160-3p (miRNAs w/seed GAGCUGA)
  47. miR-3165 (miRNAs w/seed GGUGGAU)
  48. miR-3169 (miRNAs w/seed AGGACUG)
  49. miR-3175 (miRNAs w/seed GGGGAGA)
  50. miR-3180-3p (and other miRNAs w/seed GGGGCGG)
  51. miR-3189-5p (miRNAs w/seed GCCCCAU)
  52. miR-328-5p (and other miRNAs w/seed GGGGGGC)
  53. miR-335-5p (and other miRNAs w/seed CAAGAGC)
  54. miR-339-5p (and other miRNAs w/seed CCCUGUC)
  55. miR-342-5p (and other miRNAs w/seed GGGGUGC)
  56. miR-345-5p (miRNAs w/seed CUGACUC)
  57. miR-3547 (and other miRNAs w/seed GAGCACC)
  58. miR-3584-5p (and other miRNAs w/seed GGAGGAG)
  59. miR-361-3p (miRNAs w/seed CCCCCAG)
  60. miR-3616-3p (miRNAs w/seed GAGGGCA)
  61. miR-363-5p (and other miRNAs w/seed GGGUGGA)
  62. miR-365-3p (and other miRNAs w/seed AAUGCCC)
  63. miR-3657 (and other miRNAs w/seed GUGUCCC)
  64. miR-3672 (and other miRNAs w/seed UGAGACU)
  65. miR-3682-5p (miRNAs w/seed UACUUCU)
  66. miR-3689d (and other miRNAs w/seed GGAGGUG)
  67. miR-3714 (miRNAs w/seed AAGGCAG)
  68. miR-3914 (miRNAs w/seed AGGAACC)
  69. miR-3915 (miRNAs w/seed UGAGGAA)
  70. miR-423-5p (and other miRNAs w/seed GAGGGGC)
  71. miR-4283 (miRNAs w/seed GGGGCUC)
  72. miR-4310 (and other miRNAs w/seed CAGCAUU)
  73. miR-4329 (miRNAs w/seed CUGAGAC)
  74. miR-4434 (and other miRNAs w/seed GGAGAAG)
  75. miR-4436a (and other miRNAs w/seed CAGGACA)
  76. miR-4437 (miRNAs w/seed GGGCUCA)
  77. miR-4459 (miRNAs w/seed CAGGAGG)
  78. miR-4485-5p (miRNAs w/seed CCGCCUG)
  79. miR-4487 (miRNAs w/seed GAGCUGG)
  80. miR-4527 (and other miRNAs w/seed GGUCUGC)
  81. miR-4531 (miRNAs w/seed UGGAGAA)
  82. miR-4537 (miRNAs w/seed GAGCCGA)
  83. miR-4633-3p (and other miRNAs w/seed GGAGCUA)
  84. miR-4640-5p (and other miRNAs w/seed GGGCCAG)
  85. miR-4648 (miRNAs w/seed GUGGGAC)
  86. miR-4651 (and other miRNAs w/seed GGGGUGG)
  87. miR-4667-3p (miRNAs w/seed CCCUCCU)
  88. miR-4667-5p (and other miRNAs w/seed CUGGGGA)
  89. miR-4681 (miRNAs w/seed ACGGGAA)
  90. miR-4689 (and other miRNAs w/seed UGAGGAG)
  91. miR-4690-3p (and other miRNAs w/seed CAGCCCA)
  92. miR-4695-5p (and other miRNAs w/seed AGGAGGC)
  93. miR-4715-3p (miRNAs w/seed UGCCACC)
  94. miR-4716-3p (and other miRNAs w/seed AGGGGGA)
  95. miR-4719 (miRNAs w/seed CACAAAU)
  96. miR-4723-5p (and other miRNAs w/seed GGGGGAG)
  97. miR-4731-5p (miRNAs w/seed GCUGGGG)
  98. miR-4732-5p (miRNAs w/seed GUAGAGC)
  99. miR-4747-5p (and other miRNAs w/seed GGGAAGG)
  100. miR-4755-3p (miRNAs w/seed GCCAGGC)
  101. miR-4779 (miRNAs w/seed AGGAGGG)
  102. miR-485-5p (and other miRNAs w/seed GAGGCUG)
  103. miR-486-3p (and other miRNAs w/seed GGGGCAG)
  104. miR-491-5p (and other miRNAs w/seed GUGGGGA)
  105. miR-493-5p (miRNAs w/seed UGUACAU)
  106. miR-499-5p (and other miRNAs w/seed UAAGACU)
  107. miR-4999-5p (miRNAs w/seed GCUGUAU)
  108. miR-5006-5p (miRNAs w/seed UGCCAGG)
  109. miR-5008-5p (miRNAs w/seed GAGGCCC)
  110. miR-503-5p (miRNAs w/seed AGCAGCG)
  111. miR-505-5p (and other miRNAs w/seed GGAGCCA)
  112. miR-506-5p (miRNAs w/seed AUUCAGG)
  113. miR-5088-3p (miRNAs w/seed CCCUUCU)
  114. miR-5113 (and other miRNAs w/seed CAGAGGA)
  115. miR-5129-5p (and other miRNAs w/seed UGUGGGG)
  116. miR-515-3p (and other miRNAs w/seed AGUGCCU)
  117. miR-5187-5p (miRNAs w/seed GGGAUGA)
  118. miR-5195-5p (miRNAs w/seed ACCCCUA)
  119. miR-519a-3p (and other miRNAs w/seed AAGUGCA)
  120. miR-520g-3p (and other miRNAs w/seed CAAAGUG)
  121. miR-5572 (miRNAs w/seed UUGGGGU)
  122. miR-558 (and other miRNAs w/seed GAGCUGC)
  123. miR-5624-3p (and other miRNAs w/seed UAAGGCA)
  124. miR-567 (miRNAs w/seed GUAUGUU)
  125. miR-5692a (miRNAs w/seed AAAUAAU)
  126. miR-5695 (miRNAs w/seed CUCCAAG)
  127. miR-602 (miRNAs w/seed ACACGGG)
  128. miR-6085 (and other miRNAs w/seed AGGGGCU)
  129. miR-637 (and other miRNAs w/seed CUGGGGG)
  130. miR-639 (miRNAs w/seed UCGCUGC)
  131. miR-642a-3p (and other miRNAs w/seed GACACAU)
  132. miR-6511a-5p (and other miRNAs w/seed AGGCAGA)
  133. miR-6511b-5p (and other miRNAs w/seed UGCAGGC)
  134. miR-654-3p (and other miRNAs w/seed AUGUCUG)
  135. miR-662 (miRNAs w/seed CCCACGU)
  136. miR-665 (and other miRNAs w/seed CCAGGAG)
  137. miR-669c-3p (and other miRNAs w/seed ACACACA)
  138. miR-669d-5p (and other miRNAs w/seed CUUGUGU)
  139. miR-6721-5p (miRNAs w/seed GGGCAGG)
  140. miR-6732-5p (and other miRNAs w/seed AGGGGGU)
  141. miR-6734-5p (and other miRNAs w/seed UGAGGGG)
  142. miR-6737-5p (and other miRNAs w/seed UGGGGUG)
  143. miR-6740-5p (miRNAs w/seed GUUUGGG)
  144. miR-6746-5p (miRNAs w/seed CGGGAGA)
  145. miR-6747-5p (miRNAs w/seed GGGGUGU)
  146. miR-6748-3p (miRNAs w/seed CCUGUCC)
  147. miR-6749-5p (miRNAs w/seed CGGGCCU)
  148. miR-6751-5p (and other miRNAs w/seed UGGGGGU)
  149. miR-6752-3p (miRNAs w/seed CCCUGCC)
  150. miR-6752-5p (and other miRNAs w/seed GGGGGUG)
  151. miR-6753-5p (miRNAs w/seed ACCAGGG)
  152. miR-6755-5p (miRNAs w/seed AGGGUAG)
  153. miR-6758-3p (miRNAs w/seed CUCAUUC)
  154. miR-6758-5p (and other miRNAs w/seed AGAGAGG)
  155. miR-6762-5p (and other miRNAs w/seed GGGGCCA)
  156. miR-6783-5p (miRNAs w/seed AGGGGAA)
  157. miR-6795-5p (and other miRNAs w/seed GGGGGGA)
  158. miR-6798-5p (miRNAs w/seed CAGGGGG)
  159. miR-6800-3p (miRNAs w/seed ACCUCUC)
  160. miR-6802-5p (miRNAs w/seed UAGGUGG)
  161. miR-6803-3p (miRNAs w/seed CCCUCGC)
  162. miR-6804-3p (miRNAs w/seed GCACCUG)
  163. miR-6819-3p (and other miRNAs w/seed AGCCUCU)
  164. miR-6825-5p (and other miRNAs w/seed GGGGAGG)
  165. miR-6827-5p (miRNAs w/seed GGGAGCC)
  166. miR-6835-5p (and other miRNAs w/seed GGGGGUA)
  167. miR-6836-3p (miRNAs w/seed UGCCUCC)
  168. miR-6841-5p (miRNAs w/seed AGGGUAC)
  169. miR-6859-5p (and other miRNAs w/seed AGAGGAA)
  170. miR-6864-5p (miRNAs w/seed UGAAGGG)
  171. miR-6873-5p (miRNAs w/seed AGAGGGA)
  172. miR-6880-5p (miRNAs w/seed GGUGGAG)
  173. miR-6886-3p (miRNAs w/seed GCCCUUC)
  174. miR-6890-5p (miRNAs w/seed AUGGGGU)
  175. miR-6929-5p (and other miRNAs w/seed GGGAGGA)
  176. miR-6980-5p (and other miRNAs w/seed UGGGGGG)
  177. miR-708-5p (and other miRNAs w/seed AGGAGCU)
  178. miR-7515 (miRNAs w/seed GAAGGGA)
  179. miR-766-5p (and other miRNAs w/seed GGAGGAA)
  180. miR-874-3p (miRNAs w/seed UGCCCUG)
  181. miR-879-5p (and other miRNAs w/seed GAGGCUU)
  182. miR-92a-3p (and other miRNAs w/seed AUUGCAC)
Regulates
CDK2; CDKN1A; CDK1; CDK4; CCND1; CASP3; Cyclin A; TP53; CCNE1; RB1; PCNA; PLK1; CDC25C; Cdk; BIRC5
Regulated by
TP53; TGFB1; doxorubicin; phorbol myristate acetate; cisplatin; TP73; CDKN2A; PD98059; tretinoin; butyric acid; MYC; CDKN1A; HRAS; vorinostat; beta-estradiol
Binds
CDK2; TP53; CDK4; PCNA; CCND1; CCNE1; CDK1; CCNA2; CDK6; CCND3; SP1; CCND2; CCNB1; Cyclin E; Cyclin A
Graphic indication
Role in cell
apoptosis; proliferation; growth; cell cycle progression; G1 phase; cell death; senescence; differentiation; G1/S phase transition; mitosis
Disease
  1. cancer
  2. neoplasia
  3. epithelial neoplasia
  4. epithelial cancer
  5. tumorigenesis
  6. liver cancer
  7. lung cancer
  8. esophageal cancer
  9. glomerulonephritis
  10. digestive system cancer
  11. abdominal cancer
  12. liver neoplasia
  13. hyperplasia
  14. proteinuria
  15. soft tissue sarcoma cancer
  16. growth failure
  17. arthritis
  18. weight gain
  19. hepatic steatosis
  20. hematological neoplasia
  21. lymphatic neoplasia
  22. hematologic cancer
  23. lymphoid cancer
  24. lymphocytic cancer
  25. breast cancer
  26. atherosclerosis
  27. papillomatosis
  28. benign neoplasia
  29. autoimmune disease
  30. lung adenocarcinoma
  31. head and neck squamous cell cancer
  32. head and neck squamous cell carcinoma
  33. Alzheimer disease
  34. Parkinson disease with dementia
  35. multiple endocrine neoplasia type 1
  36. acute myeloid leukemia
  37. non-Hodgkin disease
  38. ovarian cancer
  39. weight loss
  40. dyspnea
  41. insulin resistance
  42. cleft palate syndrome
  43. herniation
  44. omphalocele
  45. thoracic cancer
  46. lung carcinoma process
  47. squamous cell cancer
  48. T-cell non-Hodgkin disease
  49. pancreatic epithelial cancer
  50. skin neoplasia
  51. early precursor T-cell acute lymphoblastic leukemia
  52. hypergammaglobulinemia
  53. organismal death
  54. malignant neoplasm of esophagus
  55. gastrointestinal neoplasia
  56. stomach neoplasm
  57. colorectal neoplasm
  58. colorectal neoplasia
  59. renal clear cell cancer
  60. renal clear cell adenocarcinoma
  61. serous ovarian adenocarcinoma
  62. serous ovarian cancer
  63. lung squamous cell carcinoma
  64. squamous cell lung cancer
  65. glioblastoma cancer
  66. glioblastoma
  67. urothelial bladder carcinoma
  68. transitional cell bladder cancer
  69. cholestasis
  70. pancreatic ductal adenocarcinoma
  71. malignant urothelial neoplasm
  72. urothelial cancer
  73. non-small cell lung cancer
  74. amyotrophic lateral sclerosis
  75. HER2 negative hormone receptor negative breast cancer
  76. epileptic seizure
  77. retinoblastoma
  78. retinoblastoma cancer
  79. chondrosarcoma
  80. primitive neuroectodermal neoplasm
  81. experimental membranous nephropathy
  82. thyroid carcinoma
  83. epithelial thyroid cancer
  84. papillary thyroid carcinoma
  85. papillary thyroid cancer
  86. minimal change nephrotic syndrome
  87. diabetic nephropathy
  88. membranous glomerulonephritis
  89. immunodeficiency
  90. ovarian neoplasia
  91. ovarian neoplasm
  92. non-insulin-dependent diabetes mellitus
  93. polycystic kidney disease
  94. leiomyosarcoma
  95. hepatocellular carcinoma
  96. chronic renal failure
  97. stenosis
  98. ductal breast cancer
  99. ductal breast carcinoma
  100. basal cell skin cancer
  101. basal cell carcinoma
  102. skin cancer
  103. colon cancer
  104. pancreatic adenocarcinoma
  105. prostate cancer
  106. skin neoplasm
  107. breast carcinoma
Gene ID 1026  
UniGene
GeneBank
RCSB PDB 1AXC,  2ZVV,  2ZVW,  4RJF,  5E0U,  
DisProt DP00018  
BioGrid 107460  
MINT MINT-104203  
STRING 9606.ENSP00000244741  
ChEMBL CHEMBL5021  
DrugBank
Not Available
Guide to PHARMACOLOGY Not Available
SwissLipids Not Available
BioMuta CDKN1A  
Ensembl
KEGG hsa:1026  
PharmGKB PA104  
Reactome
Gene wiki P21  
References
  1. Fujiwara K, Daido S, Yamamoto A, Kobayashi R, Yokoyama T, Aoki H, Iwado E, Shinojima N, Kondo Y, Kondo S, Pivotal Role Of The Cyclin-dependent Kinase Inhibitor P21waf1/cip1 In Apoptosis And Autophagy., J Biol Chem.2008 Jan 4;283(1):388-97. [PMID:17959603  ]