DetailsATM

Identification
Gene Name ATM
Accession Number HAMDB886
Molecular Type kinase
Description Serine-protein kinase ATM
Synonyms ATM
Structure
Role in Autophagy
3 related item(s)

1. ATM
Gene Name ATM
Relationship with Autophagy increased activity of ATM affects autophagy
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Human
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 1
References
  1. Tripathi Dn, Chowdhury R, Trudel Lj, Tee Ar, Slack Rs, Walker Cl, Wogan Gn, Reactive Nitrogen Species Regulate Autophagy Through Atm-ampk-tsc2-mediated Suppression Of Mtorc1., Proc Natl Acad Sci U S A.2013 Aug 6;110(32):e2950-7. Doi: 10.1073/pnas.1307736110. [PMID:23878245  ]

2. ATM
Gene Name ATM
Relationship with Autophagy increased activity of ATM affects autophagy
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Mouse
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 1
References
  1. Tripathi Dn, Chowdhury R, Trudel Lj, Tee Ar, Slack Rs, Walker Cl, Wogan Gn, Reactive Nitrogen Species Regulate Autophagy Through Atm-ampk-tsc2-mediated Suppression Of Mtorc1., Proc Natl Acad Sci U S A.2013 Aug 6;110(32):e2950-7. Doi: 10.1073/pnas.1307736110. [PMID:23878245  ]

3. ATM
Gene Name ATM
Relationship with Autophagy decreased activity of ATM affects autophagy
Mutation Evidence [homozygous, knockout]
Biomarker Application not applicable
Species Evidence Mouse
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 1
References
  1. Steeves Ma, Dorsey Fc, Cleveland Jl, Targeting The Autophagy Pathway For Cancer Chemoprevention., Curr Opin Cell Biol.2010 Apr;22(2):218-25. Doi: 10.1016/j.ceb.2009.12.013. [PMID:20096553  ]
Biological Behaviors
Canonical Pathway
  1. 14-3-3-mediated Signaling
  2. 3-phosphoinositide Biosynthesis
  3. Actin Cytoskeleton Signaling
  4. Acute Myeloid Leukemia Signaling
  5. Aldosterone Signaling in Epithelial Cells
  6. AMPK Signaling
  7. Amyotrophic Lateral Sclerosis Signaling
  8. Angiopoietin Signaling
  9. Antiproliferative Role of Somatostatin Receptor 2
  10. Aryl Hydrocarbon Receptor Signaling
  11. ATM Signaling
  12. Axonal Guidance Signaling
  13. B Cell Receptor Signaling
  14. Breast Cancer Regulation by Stathmin1
  15. Cardiac Hypertrophy Signaling
  16. CCR3 Signaling in Eosinophils
  17. CD28 Signaling in T Helper Cells
  18. CD40 Signaling
  19. Cell Cycle: G1/S Checkpoint Regulation
  20. Cell Cycle: G2/M DNA Damage Checkpoint Regulation
  21. Ceramide Signaling
  22. Chronic Myeloid Leukemia Signaling
  23. Clathrin-mediated Endocytosis Signaling
  24. CNTF Signaling
  25. Colorectal Cancer Metastasis Signaling
  26. CREB Signaling in Neurons
  27. CTLA4 Signaling in Cytotoxic T Lymphocytes
  28. CXCR4 Signaling
  29. Cyclins and Cell Cycle Regulation
  30. Dendritic Cell Maturation
  31. DNA damage-induced 14-3-3σ Signaling
  32. DNA Double-Strand Break Repair by Homologous Recombination
  33. DNA Double-Strand Break Repair by Non-Homologous End Joining
  34. Docosahexaenoic Acid (DHA) Signaling
  35. EGF Signaling
  36. EIF2 Signaling
  37. Endometrial Cancer Signaling
  38. Endothelin-1 Signaling
  39. eNOS Signaling
  40. Ephrin A Signaling
  41. ErbB2-ErbB3 Signaling
  42. ErbB4 Signaling
  43. ErbB Signaling
  44. ERK/MAPK Signaling
  45. Erythropoietin Signaling
  46. Estrogen-Dependent Breast Cancer Signaling
  47. FAK Signaling
  48. Fc Epsilon RI Signaling
  49. FcγRIIB Signaling in B Lymphocytes
  50. FGF Signaling
  51. FLT3 Signaling in Hematopoietic Progenitor Cells
  52. fMLP Signaling in Neutrophils
  53. GADD45 Signaling
  54. Gap Junction Signaling
  55. GDNF Family Ligand-Receptor Interactions
  56. Germ Cell-Sertoli Cell Junction Signaling
  57. Glioblastoma Multiforme Signaling
  58. Glioma Invasiveness Signaling
  59. Glioma Signaling
  60. Glucocorticoid Receptor Signaling
  61. GM-CSF Signaling
  62. G-Protein Coupled Receptor Signaling
  63. Growth Hormone Signaling
  64. Gα12/13 Signaling
  65. Gαq Signaling
  66. HER-2 Signaling in Breast Cancer
  67. Hereditary Breast Cancer Signaling
  68. HGF Signaling
  69. HIF1α Signaling
  70. HMGB1 Signaling
  71. Human Embryonic Stem Cell Pluripotency
  72. Huntington's Disease Signaling
  73. Hypoxia Signaling in the Cardiovascular System
  74. iCOS-iCOSL Signaling in T Helper Cells
  75. IGF-1 Signaling
  76. IL-12 Signaling and Production in Macrophages
  77. IL-15 Signaling
  78. IL-17A Signaling in Airway Cells
  79. IL-17 Signaling
  80. IL-2 Signaling
  81. IL-3 Signaling
  82. IL-4 Signaling
  83. IL-6 Signaling
  84. IL-8 Signaling
  85. IL-9 Signaling
  86. ILK Signaling
  87. Insulin Receptor Signaling
  88. Integrin Signaling
  89. JAK/Stat Signaling
  90. Leptin Signaling in Obesity
  91. Leukocyte Extravasation Signaling
  92. LPS-stimulated MAPK Signaling
  93. Lymphotoxin β Receptor Signaling
  94. Macropinocytosis Signaling
  95. Melanocyte Development and Pigmentation Signaling
  96. Melanoma Signaling
  97. Molecular Mechanisms of Cancer
  98. Mouse Embryonic Stem Cell Pluripotency
  99. MSP-RON Signaling Pathway
  100. mTOR Signaling
  101. Myc Mediated Apoptosis Signaling
  102. Natural Killer Cell Signaling
  103. Neuropathic Pain Signaling In Dorsal Horn Neurons
  104. Neurotrophin/TRK Signaling
  105. NF-κB Activation by Viruses
  106. NF-κB Signaling
  107. NGF Signaling
  108. Nitric Oxide Signaling in the Cardiovascular System
  109. Non-Small Cell Lung Cancer Signaling
  110. NRF2-mediated Oxidative Stress Response
  111. Ovarian Cancer Signaling
  112. P2Y Purigenic Receptor Signaling Pathway
  113. p53 Signaling
  114. p70S6K Signaling
  115. PAK Signaling
  116. Pancreatic Adenocarcinoma Signaling
  117. Paxillin Signaling
  118. PDGF Signaling
  119. PEDF Signaling
  120. Phagosome Formation
  121. PKCθ Signaling in T Lymphocytes
  122. Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
  123. Prolactin Signaling
  124. Prostate Cancer Signaling
  125. Rac Signaling
  126. RANK Signaling in Osteoclasts
  127. Reelin Signaling in Neurons
  128. Regulation of eIF4 and p70S6K Signaling
  129. Regulation of the Epithelial-Mesenchymal Transition Pathway
  130. Relaxin Signaling
  131. Renal Cell Carcinoma Signaling
  132. Renin-Angiotensin Signaling
  133. Role of BRCA1 in DNA Damage Response
  134. Role of CHK Proteins in Cell Cycle Checkpoint Control
  135. Role of IL-17A in Arthritis
  136. Role of JAK1 and JAK3 in γc Cytokine Signaling
  137. Role of Macrophages
  138. Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
  139. Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
  140. Role of NFAT in Cardiac Hypertrophy
  141. Role of NFAT in Regulation of the Immune Response
  142. Role of Osteoblasts
  143. Osteoclasts and Chondrocytes in Rheumatoid Arthritis
  144. Role of p14/p19ARF in Tumor Suppression
  145. Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
  146. Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
  147. Role of Tissue Factor in Cancer
  148. SAPK/JNK Signaling
  149. Signaling by Rho Family GTPases
  150. Small Cell Lung Cancer Signaling
  151. Sphingosine-1-phosphate Signaling
  152. Superpathway of Inositol Phosphate Compounds
  153. Systemic Lupus Erythematosus Signaling
  154. T Cell Receptor Signaling
  155. Tec Kinase Signaling
  156. Telomerase Signaling
  157. Th1 and Th2 Activation Pathway
  158. Th1 Pathway
  159. Th2 Pathway
  160. Thrombin Signaling
  161. Thrombopoietin Signaling
  162. TR/RXR Activation
  163. Type II Diabetes Mellitus Signaling
  164. UVA-Induced MAPK Signaling
  165. UVB-Induced MAPK Signaling
  166. VEGF Family Ligand-Receptor Interactions
  167. VEGF Signaling
  168. Virus Entry via Endocytic Pathways
  169. Xenobiotic Metabolism Signaling
Targeted By miRNA
  1. miR-129-5p (miRNAs w/seed UUUUUGC)
  2. miR-182-5p (and other miRNAs w/seed UUGGCAA)
  3. miR-192-5p (and other miRNAs w/seed UGACCUA)
  4. miR-3158-3p (miRNAs w/seed AGGGCUU)
  5. miR-4263 (miRNAs w/seed UUCUAAG)
  6. miR-4484 (miRNAs w/seed AAAGGCG)
  7. miR-4509 (miRNAs w/seed CUAAAGG)
  8. miR-4680-3p (miRNAs w/seed CUGAAUU)
  9. miR-4707-3p (miRNAs w/seed GCCCGCC)
  10. miR-4736 (and other miRNAs w/seed GGCAGGU)
  11. miR-4781-3p (miRNAs w/seed AUGUUGG)
  12. miR-548aa (and other miRNAs w/seed AAAACCA)
  13. miR-548an (miRNAs w/seed AAAGGCA)
  14. miR-5681a (and other miRNAs w/seed GAAAGGG)
  15. miR-6078 (miRNAs w/seed CGCCUGA)
  16. miR-6734-5p (and other miRNAs w/seed UGAGGGG)
  17. miR-6881-3p (miRNAs w/seed UCCUCUU)
  18. miR-7150 (miRNAs w/seed UGGCAGG)
Regulates
TP53; CHEK2; H2AFX; BRCA1; CHEK1; NBN; ATM; FANCD2; BLM; ABL1; MDM2; SMC1A; TP53BP1; MDC1; RAD17
Regulated by
ATM; MRN; doxorubicin; NBN; reactive oxygen species; caffeine; ATR; camptothecin; MRE11; hydroxyurea; PRKDC; RAD50; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KAT5; TP53
Binds
TP53; NBN; ATR; BRCA1; ABL1; CHEK2; MRE11; H2AFX; PRKDC; TTI1; RAD50; ATM; KAT5; MTOR; SMC1A
Graphic indication
Role in cell
apoptosis; phosphorylation in; cell cycle progression; DNA damage response; expression in; proliferation; sensitivity; number; survival; activation in
Disease
  1. ataxia-telangiectasia
  2. breast cancer
  3. cancer
  4. lymphatic neoplasia
  5. lymphocytic cancer
  6. hematological neoplasia
  7. hematologic cancer
  8. lymphoid cancer
  9. pancreatic cancer
  10. ataxia-telangiectasia variant
  11. non-Hodgkin disease
  12. T-cell non-Hodgkin disease
  13. neoplasia
  14. breast or ovarian cancer
  15. chronic lymphocytic leukemia
  16. chromosomal instability
  17. leukemia
  18. prostate cancer
  19. growth failure
  20. epithelial neoplasia
  21. tumorigenesis
  22. early-onset breast cancer
  23. familial pancreatic cancer
  24. non-small cell lung cancer
  25. gastric cancer
  26. colorectal cancer
  27. T-cell prolymphocytic leukemia
  28. thoracic cancer
  29. mediastinal cancer
  30. thymus cancer
  31. head and neck neoplasia
  32. primary immunodeficiency disorder
  33. gastrointestinal tract cancer
  34. multiple cancers
  35. generalized dystonia
  36. insulin resistance
  37. lung adenocarcinoma
  38. atypical ataxia telangiectasia
  39. diurnal dystonia
  40. oral cancer
  41. bilateral breast cancer
  42. acute lymphocytic leukemia
  43. Hodgkin disease
  44. ocular telangiectasia
  45. multiple myeloma
  46. Richter syndrome
  47. renal clear cell adenocarcinoma
  48. renal clear cell cancer
  49. glioma formation
  50. astrocytoma
  51. breast carcinoma
  52. adenoma formation
  53. azoospermia
  54. infertility condition
  55. hypoplasia
  56. head and neck cancer
  57. lymphomagenesis
  58. benign neoplasia
  59. neurodegeneration
  60. neurological signs
  61. uterine endometrioid carcinoma
  62. endometrioid endometrial cancer
  63. serous ovarian adenocarcinoma
  64. serous ovarian cancer
  65. lung squamous cell carcinoma
  66. squamous cell lung cancer
  67. head and neck squamous cell cancer
  68. head and neck squamous cell carcinoma
  69. breast adenocarcinoma
  70. urothelial bladder carcinoma
  71. transitional cell bladder cancer
  72. hereditary neoplastic syndrome
  73. severe sepsis
  74. hydrocephalus
  75. pancreatic neoplasia
  76. pancreatic neoplasm
  77. Burkitt's lymphoma
  78. glioblastoma
  79. glioblastoma cancer
  80. HER2 negative hormone receptor negative breast cancer
  81. T cell lymphomagenesis
  82. familial breast cancer
  83. atopic dermatitis
  84. colorectal carcinoma
  85. epithelial cancer
  86. atherosclerosis
  87. immunoblastic large B-cell lymphoma
  88. rheumatoid arthritis
  89. post-transplant lymphoproliferative disorder
  90. diffuse large B-cell lymphoma
  91. follicular B-cell lymphoma
  92. follicular non-Hodgkin disease
  93. mantle cell lymphoma
  94. B-cell non-Hodgkin disease
  95. peripheral T-cell lymphoma
Gene ID 472  
UniGene
GeneBank
RCSB PDB Not Available
DisProt Not Available
BioGrid 106962  
MINT MINT-194471  
STRING 9606.ENSP00000278616  
ChEMBL CHEMBL3797  
DrugBank
Guide to PHARMACOLOGY 1934  
SwissLipids Not Available
BioMuta ATM  
Ensembl
KEGG hsa:472  
PharmGKB PA61  
Reactome
Gene wiki Ataxia_telangiectasia_mutated  
References
  1. Tripathi Dn, Chowdhury R, Trudel Lj, Tee Ar, Slack Rs, Walker Cl, Wogan Gn, Reactive Nitrogen Species Regulate Autophagy Through Atm-ampk-tsc2-mediated Suppression Of Mtorc1., Proc Natl Acad Sci U S A.2013 Aug 6;110(32):e2950-7. Doi: 10.1073/pnas.1307736110. [PMID:23878245  ]
  2. Steeves Ma, Dorsey Fc, Cleveland Jl, Targeting The Autophagy Pathway For Cancer Chemoprevention., Curr Opin Cell Biol.2010 Apr;22(2):218-25. Doi: 10.1016/j.ceb.2009.12.013. [PMID:20096553  ]