DetailsAPOL1

Identification
Gene Name APOL1
Accession Number HAMDB862
Molecular Type transporter
Description Apolipoprotein L1
Synonyms APOL1
Structure
Role in Autophagy
2 related item(s)

1. APOL1
Gene Name APOL1
Relationship with Autophagy increased activity of APOL1 increases autophagic cell death
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Human
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 2
References
  1. Wan G, Zhaorigetu S, Liu Z, Kaini R, Jiang Z, Hu Ca, Apolipoprotein L1, A Novel Bcl-2 Homology Domain 3-only Lipid-binding Protein, Induces Autophagic Cell Death., J Biol Chem.2008 Aug 1;283(31):21540-9. Doi: 10.1074/jbc.m800214200. [PMID:18505729  ]

2. APOL1
Gene Name APOL1
Relationship with Autophagy increased activity of APOL1 increases autophagic cell death
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Mouse
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 4
References
  1. Wan G, Zhaorigetu S, Liu Z, Kaini R, Jiang Z, Hu Ca, Apolipoprotein L1, A Novel Bcl-2 Homology Domain 3-only Lipid-binding Protein, Induces Autophagic Cell Death., J Biol Chem.2008 Aug 1;283(31):21540-9. Doi: 10.1074/jbc.m800214200. [PMID:18505729  ]
Biological Behaviors
Canonical Pathway
  1. Atherosclerosis Signaling
  2. Clathrin-mediated Endocytosis Signaling
  3. FXR/RXR Activation
  4. IL-12 Signaling and Production in Macrophages
  5. LXR/RXR Activation
  6. Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
Targeted By miRNA
  1. miR-122-3p (miRNAs w/seed ACGCCAU)
  2. miR-1266-5p (and other miRNAs w/seed CUCAGGG)
  3. miR-1273a (miRNAs w/seed GGCGACA)
  4. miR-1273c (miRNAs w/seed GCGACAA)
  5. miR-1273h-5p (and other miRNAs w/seed UGGGAGG)
  6. miR-1285-3p (and other miRNAs w/seed CUGGGCA)
  7. miR-1301-5p (and other miRNAs w/seed GCUCUAG)
  8. miR-1302 (and other miRNAs w/seed UGGGACA)
  9. miR-133a-5p (miRNAs w/seed GCUGGUA)
  10. miR-1343-3p (and other miRNAs w/seed UCCUGGG)
  11. miR-136-5p (miRNAs w/seed CUCCAUU)
  12. miR-149-3p (and other miRNAs w/seed GGGAGGG)
  13. miR-185-3p (and other miRNAs w/seed GGGGCUG)
  14. miR-1900 (and other miRNAs w/seed GCCGCCC)
  15. miR-1909-3p (and other miRNAs w/seed GCAGGGG)
  16. miR-1976 (and other miRNAs w/seed CUCCUGC)
  17. miR-204-3p (and other miRNAs w/seed CUGGGAA)
  18. miR-2114-5p (miRNAs w/seed AGUCCCU)
  19. miR-218-1-3p (miRNAs w/seed UGGUUCC)
  20. miR-221-5p (and other miRNAs w/seed CCUGGCA)
  21. miR-2355-3p (miRNAs w/seed UUGUCCU)
  22. miR-26a-1-3p (and other miRNAs w/seed CUAUUCU)
  23. miR-27a-5p (miRNAs w/seed GGGCUUA)
  24. miR-3072 (and other miRNAs w/seed GCCCCCU)
  25. miR-3090-3p (and other miRNAs w/seed CCCAGGU)
  26. miR-3144-5p (miRNAs w/seed GGGGACC)
  27. miR-3176 (and other miRNAs w/seed CUGGCCU)
  28. miR-3183 (and other miRNAs w/seed CCUCUCU)
  29. miR-3190-5p (miRNAs w/seed CUGGCCA)
  30. miR-3191-3p (miRNAs w/seed GGGGACG)
  31. miR-3199 (and other miRNAs w/seed GGGACUG)
  32. miR-330-5p (and other miRNAs w/seed CUCUGGG)
  33. miR-337-3p (and other miRNAs w/seed CAGCUCC)
  34. miR-3569 (and other miRNAs w/seed GAGGACA)
  35. miR-3612 (and other miRNAs w/seed GGAGGCA)
  36. miR-3620-3p (and other miRNAs w/seed CACCCUG)
  37. miR-3622b-5p (miRNAs w/seed GGCAUGG)
  38. miR-365-1-5p (and other miRNAs w/seed GGGACUU)
  39. miR-3653-5p (miRNAs w/seed CUCCUGA)
  40. miR-3675-3p (miRNAs w/seed AUCUCUA)
  41. miR-3680-3p (miRNAs w/seed UUUGCAU)
  42. miR-3691-5p (miRNAs w/seed GUGGAUG)
  43. miR-3913-5p (and other miRNAs w/seed UUGGGAC)
  44. miR-3925-3p (miRNAs w/seed CUCCAGU)
  45. miR-3926 (miRNAs w/seed GGCCAAA)
  46. miR-3945 (miRNAs w/seed GGGCAUA)
  47. miR-423-3p (miRNAs w/seed GCUCGGU)
  48. miR-4258 (miRNAs w/seed CCCGCCA)
  49. miR-4279 (miRNAs w/seed UCUCCUC)
  50. miR-4446-5p (miRNAs w/seed UUUCCCU)
  51. miR-4467 (miRNAs w/seed GGCGGCG)
  52. miR-452-5p (and other miRNAs w/seed ACUGUUU)
  53. miR-4638-5p (miRNAs w/seed CUCGGCU)
  54. miR-4652-5p (miRNAs w/seed GGGGACU)
  55. miR-4655-5p (miRNAs w/seed ACCGGGG)
  56. miR-4707-3p (miRNAs w/seed GCCCGCC)
  57. miR-4722-3p (and other miRNAs w/seed CCUGCCA)
  58. miR-4731-5p (miRNAs w/seed GCUGGGG)
  59. miR-4733-3p (and other miRNAs w/seed CACCAGG)
  60. miR-4755-3p (miRNAs w/seed GCCAGGC)
  61. miR-4768-3p (and other miRNAs w/seed CAGGAGA)
  62. miR-4777-3p (miRNAs w/seed UACCUCA)
  63. miR-483-5p (miRNAs w/seed AGACGGG)
  64. miR-490-3p (miRNAs w/seed AACCUGG)
  65. miR-504-3p (and other miRNAs w/seed GGGAGAG)
  66. miR-5131 (and other miRNAs w/seed GGCGCCC)
  67. miR-515-5p (and other miRNAs w/seed UCUCCAA)
  68. miR-5193 (miRNAs w/seed CCUCCUC)
  69. miR-541-3p (and other miRNAs w/seed GGUGGGC)
  70. miR-548av-3p (miRNAs w/seed AAACUGC)
  71. miR-5589-5p (miRNAs w/seed GCUGGGU)
  72. miR-566 (and other miRNAs w/seed GGCGCCU)
  73. miR-584-3p (miRNAs w/seed CAGUUCC)
  74. miR-597-3p (and other miRNAs w/seed GGUUCUC)
  75. miR-602 (miRNAs w/seed ACACGGG)
  76. miR-635 (and other miRNAs w/seed CUUGGGC)
  77. miR-6511b-5p (and other miRNAs w/seed UGCAGGC)
  78. miR-6717-5p (miRNAs w/seed GGCGAUG)
  79. miR-6720-3p (miRNAs w/seed GCGCCUG)
  80. miR-6721-5p (miRNAs w/seed GGGCAGG)
  81. miR-6746-3p (miRNAs w/seed AGCCGCC)
  82. miR-6747-3p (and other miRNAs w/seed CCUGCCU)
  83. miR-6749-3p (miRNAs w/seed UCCUCCC)
  84. miR-6778-3p (miRNAs w/seed GCCUCCC)
  85. miR-6790-3p (miRNAs w/seed GACCUCG)
  86. miR-6791-3p (and other miRNAs w/seed GCCUCCU)
  87. miR-6801-3p (and other miRNAs w/seed CCCCUGC)
  88. miR-6841-3p (miRNAs w/seed CCUUGCA)
  89. miR-6845-3p (and other miRNAs w/seed CUCUCCU)
  90. miR-6852-5p (and other miRNAs w/seed CCUGGGG)
  91. miR-6857-3p (miRNAs w/seed GACUGAG)
  92. miR-6862-3p (and other miRNAs w/seed CUCACCC)
  93. miR-6862-5p (and other miRNAs w/seed GGGCAUG)
  94. miR-6865-3p (and other miRNAs w/seed CACCCUC)
  95. miR-6879-3p (miRNAs w/seed GUCACCC)
  96. miR-6886-3p (miRNAs w/seed GCCCUUC)
  97. miR-6887-3p (miRNAs w/seed CCCCUCC)
  98. miR-6929-5p (and other miRNAs w/seed GGGAGGA)
  99. miR-7032-3p (and other miRNAs w/seed UCCUCUC)
  100. miR-7109-3p (miRNAs w/seed AAGCCUC)
  101. miR-7154-3p (miRNAs w/seed GGAGGAC)
  102. miR-7703 (miRNAs w/seed UGCACUC)
  103. miR-7851-3p (miRNAs w/seed ACCUGGG)
  104. miR-8053 (miRNAs w/seed GGCGAUU)
  105. miR-939-3p (miRNAs w/seed CCUGGGC)
  106. miR-941 (miRNAs w/seed ACCCGGC)
  107. miR-943 (miRNAs w/seed UGACUGU)
Regulates
P38 MAPK; Jnk; K+; MAP1LC3
Regulated by
MIR199A; SB203580; Influenza A virus (A/Udon/307/72 (H3N2)); IL27; TP53; TNF; PBMCs; IFNG; Interferon alpha; FAM20C
Binds
L-serine-O-phosphate; glycerophosphoric acid; cerebroside 3-sulfate; phosphatidylinositol 3,4-diphosphate; phosphatidylinositol 4,5-diphosphate; phosphatidylinositol-3,4,5-triphosphate; phosphatidylinositol 4-phosphate; phosphatidic acid; phosphatidylinos
Graphic indication
Role in cell
activation in; swelling; cell death; autophagic cell death by; formation in; formation
Disease
  1. focal segmental glomerulosclerosis
  2. end stage renal disease
  3. febrile seizure
  4. flu
  5. schizophrenia
  6. psoriasis
Gene ID 8542  
UniGene
GeneBank
RCSB PDB Not Available
DisProt Not Available
BioGrid 114112  
MINT Not Available
STRING 9606.ENSP00000317674  
ChEMBL Not Available
DrugBank
Not Available
Guide to PHARMACOLOGY Not Available
SwissLipids Not Available
BioMuta APOL1  
Ensembl
KEGG hsa:8542  
PharmGKB PA24904  
Reactome
Gene wiki APOL1  
References
  1. Wan G, Zhaorigetu S, Liu Z, Kaini R, Jiang Z, Hu Ca, Apolipoprotein L1, A Novel Bcl-2 Homology Domain 3-only Lipid-binding Protein, Induces Autophagic Cell Death., J Biol Chem.2008 Aug 1;283(31):21540-9. Doi: 10.1074/jbc.m800214200. [PMID:18505729  ]