DetailsAKT1

Identification
Gene Name AKT1
Accession Number HAMDB854
Molecular Type kinase
Description RAC-alpha serine/threonine-protein kinase
Synonyms AKT1
Structure
Role in Autophagy
11 related item(s)

1. AKT1
Gene Name AKT1
Relationship with Autophagy decreased activity of AKT1 increases macroautophagy of cells
Mutation Evidence [dominant, loss of function]
Biomarker Application not applicable
Species Evidence Uncategorized
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 1
References
  1. Arico S, Petiot A, Bauvy C, Dubbelhuis Pf, Meijer Aj, Codogno P, Ogier-denis E, The Tumor Suppressor Pten Positively Regulates Macroautophagy By Inhibiting The Phosphatidylinositol 3-kinase/protein Kinase B Pathway., J Biol Chem.2001 Sep 21;276(38):35243-6. [PMID:11477064  ]

2. AKT1
Gene Name AKT1
Relationship with Autophagy increased activity of AKT1 decreases autophagy of brain cancer cell lines
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Human
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 2
References
  1. Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills Gb, Kondo S, Synergistic Augmentation Of Rapamycin-induced Autophagy In Malignant Glioma Cells By Phosphatidylinositol 3-kinase/protein Kinase B Inhibitors., Cancer Res.2005 Apr 15;65(8):3336-46. [PMID:15833867  ]

3. AKT1
Gene Name AKT1
Relationship with Autophagy decreased activity of AKT1 increases autophagy of brain cancer cell lines
Mutation Evidence [dominant, loss of function]
Biomarker Application not applicable
Species Evidence Human
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 2
References
  1. Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills Gb, Kondo S, Synergistic Augmentation Of Rapamycin-induced Autophagy In Malignant Glioma Cells By Phosphatidylinositol 3-kinase/protein Kinase B Inhibitors., Cancer Res.2005 Apr 15;65(8):3336-46. [PMID:15833867  ]

4. AKT1
Gene Name AKT1
Relationship with Autophagy increased activity of AKT1 decreases macroautophagy of cells
Mutation Evidence gain-of-function
Biomarker Application not applicable
Species Evidence Uncategorized
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 1
References
  1. Arico S, Petiot A, Bauvy C, Dubbelhuis Pf, Meijer Aj, Codogno P, Ogier-denis E, The Tumor Suppressor Pten Positively Regulates Macroautophagy By Inhibiting The Phosphatidylinositol 3-kinase/protein Kinase B Pathway., J Biol Chem.2001 Sep 21;276(38):35243-6. [PMID:11477064  ]

5. AKT1
Gene Name AKT1
Relationship with Autophagy increased activity of AKT1 decreases autophagy of dopaminergic neurons,macroautophagy of cells
Mutation Evidence gain-of-function
Biomarker Application not applicable
Species Evidence Mouse
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 2
References
  1. Cheng Hc, Kim Sr, Oo Tf, Kareva T, Yarygina O, Rzhetskaya M, Wang C, During M, Talloczy Z, Tanaka K, Komatsu M, Kobayashi K, Okano H, Kholodilov N, Burke Re, Akt Suppresses Retrograde Degeneration Of Dopaminergic Axons By Inhibition Of Macroautophagy., J Neurosci.2011 Feb 9;31(6):2125-35. Doi: 10.1523/jneurosci.5519-10.2011. [PMID:21307249  ]

6. AKT1
Gene Name AKT1
Relationship with Autophagy increased activity of AKT1 decreases autophagy of muscle
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Mouse
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 2
References
  1. Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden Sj, Di Lisi R, Sandri C, Zhao J, Goldberg Al, Schiaffino S, Sandri M, Foxo3 Controls Autophagy In Skeletal Muscle In Vivo., Cell Metab.2007 Dec;6(6):458-71. [PMID:18054315  ]

7. AKT1
Gene Name AKT1
Relationship with Autophagy decreased activity of AKT1 increases autophagy of brain cancer cell lines
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Human
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 3
References
  1. Cheng Y, Ren X, Zhang Y, Patel R, Sharma A, Wu H, Robertson Gp, Yan L, Rubin E, Yang Jm, Eef-2 Kinase Dictates Cross-talk Between Autophagy And Apoptosis Induced By Akt Inhibition, Thereby Modulating Cytotoxicity Of Novel Akt Inhibitor Mk-2206., Cancer Res.2011 Apr 1;71(7):2654-63. Doi: 10.1158/0008-5472.can-10-2889. [PMID:21307130  ]
  2. Degtyarev M, De Mazière A, Orr C, Lin J, Lee Bb, Tien Jy, Prior Ww, Van Dijk S, Wu H, Gray Dc, Davis Dp, Stern Hm, Murray Lj, Hoeflich Kp, Klumperman J, Friedman Ls, Lin K, Akt Inhibition Promotes Autophagy And Sensitizes Pten-null Tumors To Lysosomotropic Agents., J Cell Biol.2008 Oct 6;183(1):101-16. Doi: 10.1083/jcb.200801099. [PMID:18838554  ]

8. AKT1
Gene Name AKT1
Relationship with Autophagy increased activity of AKT1 decreases autophagy
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Human
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 1
References
  1. Ketteler R, Sun Z, Kovacs Kf, He Ww, Seed B, A Pathway Sensor For Genome-wide Screens Of Intracellular Proteolytic Cleavage., Genome Biol.2008 Apr 3;9(4):r64. Doi: 10.1186/gb-2008-9-4-r64. [PMID:18387192  ]

9. AKT1
Gene Name AKT1
Relationship with Autophagy decreased activity of AKT1 increases autophagy of brain cancer cell lines
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Mouse
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 1
References
  1. Degtyarev M, De Mazière A, Orr C, Lin J, Lee Bb, Tien Jy, Prior Ww, Van Dijk S, Wu H, Gray Dc, Davis Dp, Stern Hm, Murray Lj, Hoeflich Kp, Klumperman J, Friedman Ls, Lin K, Akt Inhibition Promotes Autophagy And Sensitizes Pten-null Tumors To Lysosomotropic Agents., J Cell Biol.2008 Oct 6;183(1):101-16. Doi: 10.1083/jcb.200801099. [PMID:18838554  ]

10. AKT1
Gene Name AKT1
Relationship with Autophagy decreased activity of AKT1 increases autophagy of prostate cancer cell lines
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Human
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 1
References
  1. Degtyarev M, De Mazière A, Orr C, Lin J, Lee Bb, Tien Jy, Prior Ww, Van Dijk S, Wu H, Gray Dc, Davis Dp, Stern Hm, Murray Lj, Hoeflich Kp, Klumperman J, Friedman Ls, Lin K, Akt Inhibition Promotes Autophagy And Sensitizes Pten-null Tumors To Lysosomotropic Agents., J Cell Biol.2008 Oct 6;183(1):101-16. Doi: 10.1083/jcb.200801099. [PMID:18838554  ]

11. AKT1
Gene Name AKT1
Relationship with Autophagy decreased activity of AKT1 increases autophagy of prostate cancer cell lines
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Mouse
Drug Target Evidence not applicable
Expression evidence not applicable
Causal or Correlated causal
Findings 1
References
  1. Degtyarev M, De Mazière A, Orr C, Lin J, Lee Bb, Tien Jy, Prior Ww, Van Dijk S, Wu H, Gray Dc, Davis Dp, Stern Hm, Murray Lj, Hoeflich Kp, Klumperman J, Friedman Ls, Lin K, Akt Inhibition Promotes Autophagy And Sensitizes Pten-null Tumors To Lysosomotropic Agents., J Cell Biol.2008 Oct 6;183(1):101-16. Doi: 10.1083/jcb.200801099. [PMID:18838554  ]
Biological Behaviors
Canonical Pathway
  1. 14-3-3-mediated Signaling
  2. Acute Myeloid Leukemia Signaling
  3. Acute Phase Response Signaling
  4. Adipogenesis pathway
  5. AMPK Signaling
  6. Amyloid Processing
  7. Angiopoietin Signaling
  8. Axonal Guidance Signaling
  9. B Cell Receptor Signaling
  10. Cancer Drug Resistance By Drug Efflux
  11. Cardiac Hypertrophy Signaling
  12. CD28 Signaling in T Helper Cells
  13. Ceramide Signaling
  14. Chronic Myeloid Leukemia Signaling
  15. CNTF Signaling
  16. Colorectal Cancer Metastasis Signaling
  17. CREB Signaling in Neurons
  18. CTLA4 Signaling in Cytotoxic T Lymphocytes
  19. CXCR4 Signaling
  20. Dendritic Cell Maturation
  21. DNA damage-induced 14-3-3σ Signaling
  22. Docosahexaenoic Acid (DHA) Signaling
  23. EGF Signaling
  24. EIF2 Signaling
  25. Endometrial Cancer Signaling
  26. eNOS Signaling
  27. Ephrin Receptor Signaling
  28. Epithelial Adherens Junction Signaling
  29. ErbB2-ErbB3 Signaling
  30. ErbB4 Signaling
  31. ErbB Signaling
  32. ERK5 Signaling
  33. Erythropoietin Signaling
  34. Estrogen-Dependent Breast Cancer Signaling
  35. FAK Signaling
  36. Fc Epsilon RI Signaling
  37. Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
  38. FcγRIIB Signaling in B Lymphocytes
  39. FGF Signaling
  40. FLT3 Signaling in Hematopoietic Progenitor Cells
  41. FXR/RXR Activation
  42. Gap Junction Signaling
  43. G Beta Gamma Signaling
  44. Germ Cell-Sertoli Cell Junction Signaling
  45. Glioblastoma Multiforme Signaling
  46. Glioma Signaling
  47. Glucocorticoid Receptor Signaling
  48. GM-CSF Signaling
  49. G-Protein Coupled Receptor Signaling
  50. Gα12/13 Signaling
  51. Gαq Signaling
  52. HER-2 Signaling in Breast Cancer
  53. Hereditary Breast Cancer Signaling
  54. HGF Signaling
  55. HIF1α Signaling
  56. HMGB1 Signaling
  57. Human Embryonic Stem Cell Pluripotency
  58. Huntington's Disease Signaling
  59. Hypoxia Signaling in the Cardiovascular System
  60. iCOS-iCOSL Signaling in T Helper Cells
  61. IGF-1 Signaling
  62. IL-12 Signaling and Production in Macrophages
  63. IL-15 Signaling
  64. IL-17A Signaling in Airway Cells
  65. IL-17 Signaling
  66. IL-22 Signaling
  67. IL-2 Signaling
  68. IL-3 Signaling
  69. IL-4 Signaling
  70. IL-6 Signaling
  71. IL-8 Signaling
  72. ILK Signaling
  73. Inhibition of Angiogenesis by TSP1
  74. Insulin Receptor Signaling
  75. Integrin Signaling
  76. JAK/Stat Signaling
  77. Leptin Signaling in Obesity
  78. Lymphotoxin β Receptor Signaling
  79. Melanoma Signaling
  80. Molecular Mechanisms of Cancer
  81. Mouse Embryonic Stem Cell Pluripotency
  82. mTOR Signaling
  83. Myc Mediated Apoptosis Signaling
  84. Natural Killer Cell Signaling
  85. Neuregulin Signaling
  86. Neurotrophin/TRK Signaling
  87. NF-κB Activation by Viruses
  88. NF-κB Signaling
  89. NGF Signaling
  90. Nitric Oxide Signaling in the Cardiovascular System
  91. Non-Small Cell Lung Cancer Signaling
  92. NRF2-mediated Oxidative Stress Response
  93. Ovarian Cancer Signaling
  94. P2Y Purigenic Receptor Signaling Pathway
  95. p53 Signaling
  96. p70S6K Signaling
  97. Pancreatic Adenocarcinoma Signaling
  98. PEDF Signaling
  99. PI3K/AKT Signaling
  100. PI3K Signaling in B Lymphocytes
  101. Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
  102. Prostate Cancer Signaling
  103. PTEN Signaling
  104. PXR/RXR Activation
  105. RANK Signaling in Osteoclasts
  106. RAR Activation
  107. Reelin Signaling in Neurons
  108. Regulation of eIF4 and p70S6K Signaling
  109. Regulation of the Epithelial-Mesenchymal Transition Pathway
  110. Relaxin Signaling
  111. Renal Cell Carcinoma Signaling
  112. Role of Macrophages
  113. Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
  114. Role of MAPK Signaling in the Pathogenesis of Influenza
  115. Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
  116. Role of NFAT in Cardiac Hypertrophy
  117. Role of NFAT in Regulation of the Immune Response
  118. Role of Osteoblasts
  119. Osteoclasts and Chondrocytes in Rheumatoid Arthritis
  120. Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
  121. Role of PKR in Interferon Induction and Antiviral Response
  122. Role of Tissue Factor in Cancer
  123. Sertoli Cell-Sertoli Cell Junction Signaling
  124. Small Cell Lung Cancer Signaling
  125. Sphingosine-1-phosphate Signaling
  126. Systemic Lupus Erythematosus Signaling
  127. Telomerase Signaling
  128. Thrombin Signaling
  129. Tight Junction Signaling
  130. TR/RXR Activation
  131. TREM1 Signaling
  132. Type II Diabetes Mellitus Signaling
  133. UVB-Induced MAPK Signaling
  134. VEGF Family Ligand-Receptor Interactions
  135. VEGF Signaling
  136. Wnt/β-catenin Signaling
Targeted By miRNA
  1. let-7i-3p (miRNAs w/seed UGCGCAA)
  2. miR-1226-5p (and other miRNAs w/seed UGAGGGC)
  3. miR-1243 (miRNAs w/seed ACUGGAU)
  4. miR-1249-5p (and other miRNAs w/seed GGAGGGA)
  5. miR-1255b-5p (and other miRNAs w/seed GGAUGAG)
  6. miR-1273a (miRNAs w/seed GGCGACA)
  7. miR-1294 (miRNAs w/seed GUGAGGU)
  8. miR-138-5p (miRNAs w/seed GCUGGUG)
  9. miR-149-3p (and other miRNAs w/seed GGGAGGG)
  10. miR-185-5p (and other miRNAs w/seed GGAGAGA)
  11. miR-1914-3p (and other miRNAs w/seed GAGGGGU)
  12. miR-196b-3p (miRNAs w/seed CGACAGC)
  13. miR-2277-3p (miRNAs w/seed GACAGCG)
  14. miR-296-5p (miRNAs w/seed GGGCCCC)
  15. miR-298 (miRNAs w/seed GCAGAAG)
  16. miR-3064-3p (miRNAs w/seed UGCCACA)
  17. miR-3136-3p (and other miRNAs w/seed GGCCCAA)
  18. miR-3154 (miRNAs w/seed AGAAGGG)
  19. miR-3162-3p (miRNAs w/seed CCCUACC)
  20. miR-3179 (miRNAs w/seed GAAGGGG)
  21. miR-3180-3p (and other miRNAs w/seed GGGGCGG)
  22. miR-3190-5p (miRNAs w/seed CUGGCCA)
  23. miR-3200-3p (miRNAs w/seed ACCUUGC)
  24. miR-3202 (miRNAs w/seed GGAAGGG)
  25. miR-328-5p (and other miRNAs w/seed GGGGGGC)
  26. miR-3594-5p (and other miRNAs w/seed CCAGGGC)
  27. miR-3610 (miRNAs w/seed AAUCGGA)
  28. miR-3616-3p (miRNAs w/seed GAGGGCA)
  29. miR-377-5p (and other miRNAs w/seed GAGGUUG)
  30. miR-378g (miRNAs w/seed CUGGGCU)
  31. miR-423-5p (and other miRNAs w/seed GAGGGGC)
  32. miR-4268 (miRNAs w/seed GCUCCUC)
  33. miR-4270 (and other miRNAs w/seed CAGGGAG)
  34. miR-4271 (and other miRNAs w/seed GGGGAAG)
  35. miR-4433a-5p (miRNAs w/seed GUCCCAC)
  36. miR-4435 (miRNAs w/seed UGGCCAG)
  37. miR-4462 (miRNAs w/seed GACACGG)
  38. miR-4473 (miRNAs w/seed UAGUGCU)
  39. miR-4656 (and other miRNAs w/seed GGGCUGA)
  40. miR-4706 (and other miRNAs w/seed GCGGGGA)
  41. miR-4716-3p (and other miRNAs w/seed AGGGGGA)
  42. miR-4721 (and other miRNAs w/seed GAGGGCU)
  43. miR-4723-5p (and other miRNAs w/seed GGGGGAG)
  44. miR-4731-5p (miRNAs w/seed GCUGGGG)
  45. miR-4738-5p (miRNAs w/seed CCAGCGC)
  46. miR-4740-3p (miRNAs w/seed CCCGAGA)
  47. miR-4747-5p (and other miRNAs w/seed GGGAAGG)
  48. miR-4783-3p (miRNAs w/seed CCCGGUG)
  49. miR-5008-5p (miRNAs w/seed GAGGCCC)
  50. miR-501-3p (and other miRNAs w/seed AUGCACC)
  51. miR-512-3p (miRNAs w/seed AGUGCUG)
  52. miR-548aa (and other miRNAs w/seed AAAACCA)
  53. miR-548as-3p (miRNAs w/seed AAAACCC)
  54. miR-548d-3p (and other miRNAs w/seed AAAAACC)
  55. miR-5580-5p (and other miRNAs w/seed GCUGGCU)
  56. miR-5627-5p (and other miRNAs w/seed GAGGGUG)
  57. miR-564 (and other miRNAs w/seed GGCACGG)
  58. miR-6089 (miRNAs w/seed GAGGCCG)
  59. miR-633 (miRNAs w/seed UAAUAGU)
  60. miR-6512-5p (miRNAs w/seed ACCAUUA)
  61. miR-6515-5p (miRNAs w/seed UGGAGGG)
  62. miR-6729-3p (miRNAs w/seed CAUCCCC)
  63. miR-6734-5p (and other miRNAs w/seed UGAGGGG)
  64. miR-6771-3p (miRNAs w/seed AAACCCC)
  65. miR-6772-3p (miRNAs w/seed UGCUCCU)
  66. miR-6795-5p (and other miRNAs w/seed GGGGGGA)
  67. miR-6815-3p (miRNAs w/seed GGCUUCU)
  68. miR-6820-5p (miRNAs w/seed GCGGCAG)
  69. miR-6825-5p (and other miRNAs w/seed GGGGAGG)
  70. miR-6886-5p (miRNAs w/seed CCGCAGG)
  71. miR-7064-3p (and other miRNAs w/seed AGGGCCC)
  72. miR-891b (miRNAs w/seed GCAACUU)
Regulates
GSK3B; BAD; AKT1; NOS3; MTOR; FOXO1; FOXO3; NFkB (complex); Gsk3; CASP3; MDM2; CASP9; CHUK; p70 S6k; CDKN1B
Regulated by
Ins1; LY294002; PI3K (complex); wortmannin; IGF1; PDPK1; Insulin; PTEN; INS; EGF; AKT1; Pdgf (complex); TNF; hydrogen peroxide; ILK
Binds
GSK3B; MTOR; GSK3A; MDM2; BAD; RICTOR; HSP90AA1; PDPK1; FOXO1; PPP2CA; TCL1A; AR; PAK1; AKT1; PRKCZ
Graphic indication
Role in cell
apoptosis; survival; proliferation; migration; cell death; growth; expression in; phosphorylation in; activation in; size
Disease
  1. neoplasia
  2. epithelial neoplasia
  3. cancer
  4. metastasis
  5. epithelial cancer
  6. breast cancer
  7. tumorigenesis
  8. glioblastoma
  9. breast carcinoma
  10. diabetes mellitus
  11. non-Hodgkin lymphoma
  12. lung squamous cell carcinoma
  13. squamous cell lung cancer
  14. glioblastoma cancer
  15. familial schizophrenia
  16. Cowden disease type 6
  17. proteus syndrome
  18. obesity
  19. dyspnea
  20. thoracic cancer
  21. lung cancer
  22. oligozoospermia
  23. hypoplasia
  24. breast or ovarian cancer
  25. colorectal cancer
  26. prostate cancer
  27. non-insulin-dependent diabetes mellitus
  28. hyperactive behavior
  29. hyperglycemia
  30. schizophrenia
  31. glioma
  32. lymphatic neoplasia
  33. abdominal cancer
  34. impaired glucose tolerance
  35. lymphadenopathy
  36. splenomegaly
  37. Wallerian degeneration
  38. Merkel-cell carcinoma
  39. Merkel cell cancer
  40. glioma formation
  41. central nervous system cancer
  42. glioma cancer
  43. pulmonary sclerosing hemangioma
  44. pulmonary fibrosis
  45. squamous cell skin cancer
  46. skin squamous cell carcinoma
  47. survival
  48. uterine endometrioid carcinoma
  49. endometrioid endometrial cancer
  50. head and neck squamous cell carcinoma
  51. head and neck squamous cell cancer
  52. breast adenocarcinoma
  53. multiple myeloma
  54. aortic valve calcification
  55. HER2 negative hormone receptor negative breast cancer
  56. ovarian cancer
  57. colitis
  58. gastrointestinal tract cancer
  59. gastrointestinal neoplasia
  60. gastroesophageal cancer
  61. gastric cancer
  62. pelvic cancer
  63. female genital tract cancer
  64. epithelial endometrial cancer
  65. urogenital cancer
  66. endometrial cancer
  67. uterine cancer
  68. head and neck neoplasia
  69. head and neck cancer
  70. epithelial thyroid cancer
  71. lung metastasis
  72. advanced cancer
  73. thyroid cancer
  74. lung carcinoma process
  75. non-small cell lung cancer
  76. systemic lupus erythematosus
  77. renal clear cell adenocarcinoma
  78. renal clear cell cancer
  79. atopic dermatitis
  80. endothelial dysfunction
  81. endotoxin shock response
  82. thymoma
  83. productive infection by HIV-1
  84. infection by HIV-1
  85. anemia
  86. hepatocellular adenoma
  87. Huntington disease
  88. leukemia
  89. liver adenoma
  90. hyperplasia
  91. digestive system cancer
  92. anaphylaxis
  93. hypotrophy
  94. prostatic intraepithelial neoplasia
Gene ID 207  
UniGene
GeneBank
RCSB PDB 1H10,  1UNP,  1UNQ,  1UNR,  2UVM,  2UZR,  2UZS,  3CQU,  3CQW,  3MV5,  3MVH,  3O96,  3OCB,  3OW4,  3QKK,  3QKL,  3QKM,  4EJN,  4EKK,  4EKL,  4GV1,  5KCV,  
DisProt DP00304  
BioGrid 106710  
MINT MINT-203775  
STRING 9606.ENSP00000270202  
ChEMBL CHEMBL4282  
DrugBank
Guide to PHARMACOLOGY 1479  
SwissLipids Not Available
BioMuta AKT1  
Ensembl
KEGG hsa:207  
PharmGKB PA24684  
Reactome
Gene wiki AKT1  
References
  1. Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills Gb, Kondo S, Synergistic Augmentation Of Rapamycin-induced Autophagy In Malignant Glioma Cells By Phosphatidylinositol 3-kinase/protein Kinase B Inhibitors., Cancer Res.2005 Apr 15;65(8):3336-46. [PMID:15833867  ]
  2. Arico S, Petiot A, Bauvy C, Dubbelhuis Pf, Meijer Aj, Codogno P, Ogier-denis E, The Tumor Suppressor Pten Positively Regulates Macroautophagy By Inhibiting The Phosphatidylinositol 3-kinase/protein Kinase B Pathway., J Biol Chem.2001 Sep 21;276(38):35243-6. [PMID:11477064  ]
  3. Cheng Hc, Kim Sr, Oo Tf, Kareva T, Yarygina O, Rzhetskaya M, Wang C, During M, Talloczy Z, Tanaka K, Komatsu M, Kobayashi K, Okano H, Kholodilov N, Burke Re, Akt Suppresses Retrograde Degeneration Of Dopaminergic Axons By Inhibition Of Macroautophagy., J Neurosci.2011 Feb 9;31(6):2125-35. Doi: 10.1523/jneurosci.5519-10.2011. [PMID:21307249  ]
  4. Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden Sj, Di Lisi R, Sandri C, Zhao J, Goldberg Al, Schiaffino S, Sandri M, Foxo3 Controls Autophagy In Skeletal Muscle In Vivo., Cell Metab.2007 Dec;6(6):458-71. [PMID:18054315  ]
  5. Cheng Y, Ren X, Zhang Y, Patel R, Sharma A, Wu H, Robertson Gp, Yan L, Rubin E, Yang Jm, Eef-2 Kinase Dictates Cross-talk Between Autophagy And Apoptosis Induced By Akt Inhibition, Thereby Modulating Cytotoxicity Of Novel Akt Inhibitor Mk-2206., Cancer Res.2011 Apr 1;71(7):2654-63. Doi: 10.1158/0008-5472.can-10-2889. [PMID:21307130  ]
  6. Degtyarev M, De Mazière A, Orr C, Lin J, Lee Bb, Tien Jy, Prior Ww, Van Dijk S, Wu H, Gray Dc, Davis Dp, Stern Hm, Murray Lj, Hoeflich Kp, Klumperman J, Friedman Ls, Lin K, Akt Inhibition Promotes Autophagy And Sensitizes Pten-null Tumors To Lysosomotropic Agents., J Cell Biol.2008 Oct 6;183(1):101-16. Doi: 10.1083/jcb.200801099. [PMID:18838554  ]
  7. Ketteler R, Sun Z, Kovacs Kf, He Ww, Seed B, A Pathway Sensor For Genome-wide Screens Of Intracellular Proteolytic Cleavage., Genome Biol.2008 Apr 3;9(4):r64. Doi: 10.1186/gb-2008-9-4-r64. [PMID:18387192  ]