Detailspifithrin alpha

Identification
Chemical Name pifithrin alpha
Accession Number HAMDB832
Alternative Names Not Available
IUPAC Name Not Available
Formula Not Available
Canonical SMILES Not Available
Structure
Physicochemical Properties
Molecular Weight Molecular weight
Hbond Donor Number of hydrogen bond acceptor atoms (not counting acidic atoms but counting atoms that are both hydrogen bond donors and acceptors such as -OH).
Hbond Acceptor Number of hydrogen bond donor atoms (not counting basic atoms but counting atoms that are both hydrogen bond donors and acceptors such as -OH).
logP (o/w) Log of the octanol/water partition coefficient (including implicit hydrogens). [LOGP 1998]
logS Log of the aqueous solubility (mol/L).
MR Molecular refractivity (including implicit hydrogens).
SlogP Log of the octanol/water partition coefficient. [Crippen 1999]
TPSA Polar surface area (Å2) calculated using group contributions to approximate the polar surface area from connection table information only. The parameterization is that of Ertl et al. [Ertl 2000].
logD (PH=7) The octanol/water distribution coefficient at pH 7.
pKa (PH=7) The pKa of the reaction that removes a proton from the ensemble of states with a hydrogen count equal to the input structure.
pKb (PH=7) The pKb of the reaction that adds a proton from the ensemble of states with a hydrogen count equal to the input structure.
Lipinski druglike One if and only if lip_violation < 2 otherwise zero.
Solubility
Role in Autophagy
2 related item(s)

1. pifithrin alpha
Chemical Name pifithrin alpha
Relationship with Autophagy increased activity of pifithrin alpha increases autophagy of fibroblasts
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Mouse
Drug Target Evidence not applicable
Expression Evidence not applicable
Causal or Correlated causal
Findings 5
References
  1. Criollo A, Senovilla L, Authier H, Maiuri Mc, Morselli E, Vitale I, Kepp O, Tasdemir E, Galluzzi L, Shen S, Tailler M, Delahaye N, Tesniere A, De Stefano D, Younes Ab, Harper F, Pierron G, Lavandero S, Zitvogel L, Israel A, Baud V, Kroemer G, The Ikk Complex Contributes To The Induction Of Autophagy., Embo J.2010 Feb 3;29(3):619-31. Doi: 10.1038/emboj.2009.364. [PMID:19959994  ]

2. pifithrin alpha
Chemical Name pifithrin alpha
Relationship with Autophagy increased activity of pifithrin alpha increases autophagy of cervical cancer cell lines
Mutation Evidence wild type
Biomarker Application not applicable
Species Evidence Uncategorized
Drug Target Evidence not applicable
Expression Evidence not applicable
Causal or Correlated causal
Findings 5
References
  1. Criollo A, Senovilla L, Authier H, Maiuri Mc, Morselli E, Vitale I, Kepp O, Tasdemir E, Galluzzi L, Shen S, Tailler M, Delahaye N, Tesniere A, De Stefano D, Younes Ab, Harper F, Pierron G, Lavandero S, Zitvogel L, Israel A, Baud V, Kroemer G, The Ikk Complex Contributes To The Induction Of Autophagy., Embo J.2010 Feb 3;29(3):619-31. Doi: 10.1038/emboj.2009.364. [PMID:19959994  ]
Biological Behaviors
Gene Name Not Available
Target Not Available
Pathway Not Available
Biological Description Not Available
Research Area Not Available
Category Not Available
In Vitro Not Available
In Vivo Not Available
Clinical Trial Not Available
CAS Numbers Not Available
Pubchem Not Available
HMDB Not Available
DrugBank Not Available
References
Not Available